HORDB

ID: hor001931
Uniprot ID: Q9PUR1
Protein name: Glucagon-like peptide 1-I
Gene name: gcg1
Organism: Petromyzon marinus (Sea lamprey)
Family: Glucagon family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Petromyzon (genus), Petromyzontidae (family), Petromyzontiformes (order), Hyperoartia (class), Cyclostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050896 response to stimulus
GO CC: GO:0005576 extracellular region

Sequence: HADGTFTNDMTSYLDAKAARDFVSWLARSDKS
Length: 32(82-113)
Propeptide: MSDPGFLAAPVLLLLLVSLASASLEQAASRDDDSAERPLSKRHSEGTFTSDYSKYLENKQAKDFVRWLMNAKRGGSELQRRHADGTFTNDMTSYLDAKAARDFVSWLARSDKSRRDGGDHLAENSEDKRHAEDVNALLDRTMAKTFIEWLEKQNSNDQTD
Signal peptide: MSDPGFLAAPVLLLLLVSLASA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001931_AF2.pdb

hor001931_ESM.pdb

Mass:	413102	Formula:	C155H234N44O52S
Absent amino acids:	CEIPQ	Common amino acids:	AD
pI:	5.59	Basic residues:	5
Polar residues:	10	Hydrophobic residues:	11
Hydrophobicity:	-64.38	Boman Index:	-8278
Half-Life:	3.5 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	49.06
Instability Index:	1521.88	Extinction Coefficient cystines:	6990
Absorbance 280nm:	225.48

PubMed ID: 8405897
Title: Primary Structures of Glucagon and Glucagon-Like Peptide Isolated From the Intestine of the Parasitic Phase Lamprey Petromyzon Marinus